Single word for: calculator "for whole dataset at a time"
Solution 1:
There is nothing wrong with "whole-dataset" It baffles me that people writing papers use the most abstruse words they can find. Is this supposed to impress their readers? All it does is to hide their work in a morass of other incomprehensible vocabulation. (intentional irony)
My suggestion
Novel whole-dataset calculator for identifying patient's comorbidity status
I might add "efficient" because that is what makes the difference when computing.
P.S. Just checking. Do you mean "patient's" or "patients'". If the former, then I think you are definitive onto something very useful.