Is it possible to set up PHP-FPM with different pool-options (xdebug enabled / xdebug disabled)

Solution 1:

Unfortunately you can't load different modules or version of modules for each FPM pool. So far I've created multiple completely separate instances of PHP-FPM in similar situations.

Solution 2:

Yes, but the extra pool also needs to run under a separate service. That service can use the same binaries, but needs its own conf files and (some) dirs. How to achieve this depends on your system and its service manager. I used this answer as a basis because I have systemd.