Multiple search and replace in one line

Try

:%s/aaa/bbb/e | %s/111/222/e

and read

:help :s_flags

especially the entry under [e]:

 When the search pattern fails, do not issue an error message and, in
 particular, continue in maps as if no error occurred.  This is most
 useful to prevent the "No match" error from breaking a mapping.  Vim
 does not suppress the following error messages, however:
 Regular expressions can't be delimited by letters
 \ should be followed by /, ? or &
 No previous substitute regular expression
 Trailing characters
 Interrupted