Python pandas: how to remove nan and -inf values

Use pd.DataFrame.isin and check for rows that have any with pd.DataFrame.any. Finally, use the boolean array to slice the dataframe.

df[~df.isin([np.nan, np.inf, -np.inf]).any(1)]

             time    X    Y  X_t0     X_tp0   X_t1     X_tp1   X_t2     X_tp2
4        0.037389    3   10     3  0.333333    2.0  0.500000    1.0  1.000000
5        0.037393    4   10     4  0.250000    3.0  0.333333    2.0  0.500000
1030308  9.962213  256  268   256  0.000000  256.0  0.003906  255.0  0.003922

You can replace inf and -inf with NaN, and then select non-null rows.

df[df.replace([np.inf, -np.inf], np.nan).notnull().all(axis=1)]  # .astype(np.float64) ?

or

df.replace([np.inf, -np.inf], np.nan).dropna(axis=1)

Check the type of your columns returns to make sure they are all as expected (e.g. np.float32/64) via df.info().

df.replace([np.inf, -np.inf], np.nan)

df.dropna(inplace=True)