Spotlight, infinite indexing, secondary drives, and NAS

There a command line tool which you could use: mdutil. Open Terminal.app application and try the following:

To check the indexing status (on|off) for a volume:

thomas$ mdutil -s /Volumes/nfs-spotlight/
/Volumes/nfs-spotlight:
    Indexing enabled.

...and to turn indexing off:

thomas$ sudo mdutil -i off /Volumes/nfs-spotlight/
Password:
/Volumes/nfs-spotlight:
    Indexing disabled.

...or even better disable spotlight activities:

thomas$ sudo mdutil -d /Volumes/nfs-spotlight/
/Volumes/nfs-spotlight:
    Indexing and searching disabled.

Calling mdutil without any parameter shows all the allowed parameters

It works with my NAS nfs mount but then it's much smaller than 100TB. It's worth a try nevertheless.