How to disable middle button showing a page thumbnail in Adobe Reader?
Solution 1:
AFAIK there is not a direct way to do this so you have to use some trick like AutoHotkey. There is another question I found where user is using mouse wheel as hand in Adobe reader.
The best way to set the keys according to your wish and do whatever you want to. But I think this will cause to not scroll down through the mouse wheel after this.