Solution 1:

This seems to be a reliable, simple way to get the "entry" or main assembly for a web app.

If you put controllers in a separate project, you may find that the base class of ApplicationInstance is not in the same assembly as your MVC project that contains the Views - but, this setup seems pretty rare (I mention it because I've tried this setup at one point, and a while back a few blogs supported the idea).

    static private Assembly GetWebEntryAssembly()
    {
        if (System.Web.HttpContext.Current == null ||
            System.Web.HttpContext.Current.ApplicationInstance == null) 
        {
            return null;
        }

        var type = System.Web.HttpContext.Current.ApplicationInstance.GetType();
        while (type != null && type.Namespace == "ASP") {
            type = type.BaseType;
        }

        return type == null ? null : type.Assembly;
    }

Solution 2:

In my case, I needed to get the "entry assembly" for a web app before System.Web.HttpContext.Current.ApplicationInstance is initialized. Also, my code needed to work for a variety of app types (window services, desktop apps, etc), and I don't like to pollute my common code with Web concerns.

I created a custom assembly-level attribute, which can be declared in the AssembyInfo.cs file of an assembly which you want to designate as the entry point assembly. Then, you just call the attribute's static GetEntryAssembly method to get the entry assembly. If Assembly.GetEntryAssembly returns non-null, that is used, otherwise it searches through loaded assemblies for the one with the custom attribute. The result is cached in a Lazy<T>.

using System;
using System.Collections.Generic;
using System.Linq;
using System.Reflection;

namespace EntryAssemblyAttributeDemo
{
    /// <summary>
    /// For certain types of apps, such as web apps, <see cref="Assembly.GetEntryAssembly"/> 
    /// returns null.  With the <see cref="EntryAssemblyAttribute"/>, we can designate 
    /// an assembly as the entry assembly by creating an instance of this attribute, 
    /// typically in the AssemblyInfo.cs file.
    /// <example>
    /// [assembly: EntryAssembly]
    /// </example>
    /// </summary>
    [AttributeUsage(AttributeTargets.Assembly)]
    public sealed class EntryAssemblyAttribute : Attribute
    {
        /// <summary>
        /// Lazily find the entry assembly.
        /// </summary>
        private static readonly Lazy<Assembly> EntryAssemblyLazy = new Lazy<Assembly>(GetEntryAssemblyLazily);

        /// <summary>
        /// Gets the entry assembly.
        /// </summary>
        /// <returns>The entry assembly.</returns>
        public static Assembly GetEntryAssembly()
        {
            return EntryAssemblyLazy.Value;
        }

        /// <summary>
        /// Invoked lazily to find the entry assembly.  We want to cache this value as it may 
        /// be expensive to find.
        /// </summary>
        /// <returns>The entry assembly.</returns>
        private static Assembly GetEntryAssemblyLazily()
        {
            return Assembly.GetEntryAssembly() ?? FindEntryAssemblyInCurrentAppDomain();
        }

        /// <summary>
        /// Finds the entry assembly in the current app domain.
        /// </summary>
        /// <returns>The entry assembly.</returns>
        private static Assembly FindEntryAssemblyInCurrentAppDomain()
        {
            var assemblies = AppDomain.CurrentDomain.GetAssemblies();
            var entryAssemblies = new List<Assembly>();
            foreach (var assembly in assemblies)
            {
                // Note the usage of LINQ SingleOrDefault.  The EntryAssemblyAttribute's AttrinuteUsage 
                // only allows it to occur once per assembly; declaring it more than once results in 
                // a compiler error.
                var attribute =
                    assembly.GetCustomAttributes().OfType<EntryAssemblyAttribute>().SingleOrDefault();
                if (attribute != null)
                {
                    entryAssemblies.Add(assembly);
                }
            }

            // Note that we use LINQ Single to ensure we found one and only one assembly with the 
            // EntryAssemblyAttribute.  The EntryAssemblyAttribute should only be put on one assembly 
            // per application.
            return entryAssemblies.Single();
        }
    }
}

Solution 3:

The algorithm proposed in the question did indeed work for me, whereas the method using System.Web.HttpContext.Current.ApplicationInstance didn't. I think my problem is that the old-style ASP.Net application for which I need a solution lacks a global.asax handler.

This shorter solution also worked for me and I think will generally work on the condition that the page handler is defined in the front-end assembly:

    private static Assembly GetMyEntryAssembly()
    {
      if ((System.Web.HttpContext.Current == null) || (System.Web.HttpContext.Current.Handler == null))
        return Assembly.GetEntryAssembly(); // Not a web application
      return System.Web.HttpContext.Current.Handler.GetType().BaseType.Assembly;
    }

My application is an ASP.Net 4.x web forms application. For this application type, HttpContext.Current.Handler is the code module containing the entry point of the current request handler. Handler.GetType().Assembly is a temporary ASP.Net assembly, but Handler.GetType().BaseType.Assembly is the true "entry assembly" of my application. I am curious if the same works for various other ASP.Net application types.