Logitech Options won't let me change the "Keystroke assignment" assigned to a mouse button anymore

Solution 1:

It seems to come down to accessibility.

  1. Made sure I had all of the latest software loaded,
  2. Found the Logi Options Daemon app inside the application in a Support folder - right click on the app and chose "Show Package Contents"; and copied it to /Library/Application Support/Logitech/Logitech Options
  3. Added the Logi Options Daemon app to Input Monitoring in the System preferences.
    And finally when it was still not working…
  4. Deleted Logi Options Daemon, and Logi Options from System Preferences/Accessibility; and then put them back.
  5. Restarted. Voilà.