LINK : fatal error LNK1104: cannot open file 'D:\...\MyProj.exe'

Had this issue after a reinstall today. Make sure the Application Experience service is started and not set to disabled. If its set to manual, I believe VS will start it.

I'm aware this is quite old but I just had the same problem with Visual Studio 2010 all patched up so others may still run into this.

Adding my project path to "Exluded Items" in my AVG anti-virus settings appears to have fixed the problem for me.

Try disabling any anti-virus/resident shield and see if it fixes the problem. If so, add your project path to excluded directories in your AV config.

You probably had a stray build process that was locking the executable, and it (the stray process) didn't get cleaned up. In that case, shut down visual studio, open up process explorer, and nuke every process you can find that is related to visual studio. Then open up visual studio again and try rebuilding your project.

the file can be locked because it is being run now. Try killing the process with a task manager.

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