How do I do Home and End in iterm2?

^ ControlA and ^ ControlE are keybinding in Bash and ZSH, not in iTerm (or Terminal).

If you want custom bindings within iTerm, you will need to bind the actual keyboard sequence in the keybinding. "Start of Line" and "End of Line" are descriptors, not the actual key strokes.

So, to do this you'd need to send ^ ControlA for Home via their Hex Codes. In this case, the codes would be 0x01 for "start of text" (^A) and 0x05 for "ENQ" (^E).

In the image below, you can add a new binding in Preferences → Keys → Key Bindings

1. Click on + to add a new binding
2. Click on Record in the dialog box
3. Press your desired key (Home in this case).
4. Select your Action (you can scroll or search). Select "Send Hex Code"
5. Enter the Hex Code (0x01 for "start of text")
6. Test it out!

The accepted solution proposed by Allan is not optimal, as this keybinding affects *ALL* applications that are executed on the terminal and this key remapping would mean that some applications won't work as expected:

For example, if you use 'vi' then the keys 'Home' and 'End' no longer work after this key binding (those keys work ok if you don't do the proposed key binding)

A better solution is to do the key mapping on the shell itself:

In zsh (the default shell being used by macos nowadays), just add this in ~/.zshrc:

bindkey '\e[H'    beginning-of-line
bindkey '\e[F'    end-of-line

and Home and End keys will work ok in both the command line and vi