Quotation Marks Around Nicknames?

I would understand if the nickname was around quotation marks if the full name was presented as well:

"His name is O'Shea 'Ice Cube' Jackson Sr."

But what if you referred to a person only by their nickname?

With quotation marks:

"Hey, 'Ice Cube,' how's it going?"

Without quotation marks:

"Hey, Ice Cube, how's it going?"

Would the quotation marks be necessary?

Quotes around the nickname when it is used alone are not needed for exactly the same reason they are needed in a full-blown reference such as O'Shea 'Ice Cube' Jackson Sr.

A nickname is defined as an extra name; meaning one that is used instead of, ie in the same way as, the person's real name, not part of it. (eg https://www.google.co.uk/search?q=nickname&rlz=1C5CHFA_enGB718GB718&oq=nickname&aqs=chrome..69i57j69i60.2540j0j7&sourceid=chrome&ie=UTF-8)

The full meaning of O'Shea 'Ice Cube' Jackson Sr is O'Shea Jackson Sr, often called Ice Cube instead, in rather the same way that a newspaper or magazine (possibly patronizingly) this is defined as a 'nickname'

Defining the nickname like that is a wholly different thing from actually using it, which is why Are you Ice Cube? needs no more quotes than does Are you O'Shea Jackson?

My English teacher's name was Frances Dingle. When she married Rutledge Dingle, she became Mrs. Rutledge Dingle. However, everyone referred to her as "Miss Fran" Dingle. She said that since that was not her real name, it should be set off in quotation marks.