Invert color in Preview

The Command Option CTRL 8 keypress inverts the video signal of the display. It does not alter the 'true' colour properties of images, nor does it affect printing.

You can effect an inverse colour transformation to an image in Preview, using the method described here:

https://osxdaily.com/2019/07/27/how-invert-image-mac-preview/

Essentially, this involves switching the position of the Black point and White point sliders in the Adjust Colors panel.