What are the strongest combinations of Pantheon Spirits for AFK?

In Cookie Clicker, there is a Pantheon that lets you slot Spirits to get bonuses. I would like to know which Spirits are best for an AFK/low attention build and where they should be slotted.

Right now, I have Mokalsium (milk power up) in Diamond, Skruuia (wrinkler power up) in Ruby, and Holobore (base CPS up) in Jade. I assume these three are the best for AFK builds, but I do not know if their slotting is as optimal as it could be, which is what led me to asking this question.

As for my run, I am currently in what I assume to be the end game. I have 377/439 for achievements and my current CPS (without wrinklers) is 221.526 undecillion.

You have Mokalsium in the right place (milk is op), but you should move Holobre to Ruby and put Jeremy in Jade, since their CPS increase is actually quite substantial. Using Skruuia is a common mistake, because while its description says that Wrinklers consume more cookies, they actually just return more when popped, so right before you pop your wrinklers, slot Skruuia in Diamond, pop them, and then unslot them again. If you want to farm sugar lumps though, I'd replace Holobre or Jeremy with Rigidel. (Side note- Rigidel's effect is only active while the game is open.)