Installing Dishonored game from disc

You need to first follow this guide How to install and configure Wine? to the letter. Please make sure that after finishing the guide you end up with a 32-Bit WinePrefix. This should leave you with Wine 1.6 which is the most recent one and with a list of components already installed. The winetricks list-installed command in the terminal should look similar to this list:

cyrex@cyrex:~$ winetricks list-installed
amstream
d3dcompiler_43
d3dx10
d3dx11_42
d3dx11_43
d3dx9_26
d3dx9_28
d3dx9_31
d3dx9_35
d3dx9_36
d3dx9_39
d3dx9_42
d3dx9_43
d3dx9
devenum
dirac
directmusic
directplay
directx9
dmsynth
dotnet20
dotnet40
dsound
ffdshow
icodecs
l3codecx
mfc42
mspatcha
msscript
msvcirt
physx
quartz
vcrun2008
vcrun2010
vcrun6sp6
vcrun6
winhttp
wininet
wsh56vb
wsh57
xact_jun2010
xact
xinput
xna40

Of this list, to have Dishonored working, even with all DLC installed, you need to have at least the following components from the list above:

d3dx11_43
d3dx9_26
d3dx9_28
d3dx9_31
d3dx9_35
d3dx9_36
d3dx9_39
d3dx9_42
d3dx9_43
d3dx9
directmusic
directplay
directx9
dotnet40
dsound
mfc42
mspatcha
msscript
msvcirt
physx
quartz
vcrun2008
vcrun2010
vcrun6sp6
vcrun6
winhttp
wininet
wsh56vb
wsh57
xact_jun2010
xact
xinput
xna40

Now simply run the installer and you should see the following:

Start the installer and when it finishes it is important to check the options that matter:

After which you should be able to simply play the game. My recommendations are to play the game in Windows 7 mode because in Windows XP sometimes there are keyboard keys stuck and sound issues. The end result should be like this:

Here is a video showing how Dishonored will look: http://www.youtube.com/watch?v=_5u-cxCGG9Y