Does it matter the region on psn?

Although the system is Spanish, which is - I guess - a normal thing for a guy living in Spain, my rough guess is that games usually allow you to modify the setting for the game content language. If the issue comes from the game supporting only Spanish, then I think it's time to buy a more "Europe-oriented" game ? I live in Middle East, and I prefer buying Europe-supporting games because of their support of French (and because it's WAY cheaper but shhh).