Is it possible to scale up windowed SpaceChem?
The maximum resolution appears to be 1024x768
For confirmation, navigate to the following directory on your computer:
%LOCALAPPDATA%\Zachtronics Industries\SpaceChem
Edit config.ini and change the windowWidth and windowHeight options.
This will adjust the size of the window, but unfortunately, the actual pixels of the game do not scale to fill the window.
(As a side note, the first splash screen that reads "A Game By Zachtronics Industries" does scale very nicely up to a very high resolution.)