Is there the dark mode (inverted colors) in the 'Preview' Application for PDF reading? [duplicate]
I had the same problem so I wrote simple and free app for Mac to read PDFs in negative. App offers two negative modes (colour inversion and colour inversion with sepia).
It is called Negative and it is free on the Mac App Store
While there is not an inverted color scheme for Preview, you can invert the screen colors for the entire system by pressing
Command-Option-Control-8
Press the sequence again to restore the default color scheme.
I use Adobe PDF Reader to read PDF books. In Preferences > Accessibility > Document Colors Options I set "Replace Document Colors" and "Custom Color". Page Background: black and Document Text: a ordinary dark grey.
So my default PDF reader is Preview with regular color, but I open PDF books with customized Adobe Reader.