How do I list multiple married couples names on an inviation

I am listing multiple married couples as hosts for a wedding shower. Do I have to use Mr. & Mrs. before every name? The space on the invitation is limited.

If you're mentioning their names to honour their contribution to the event, it would make sense to allow the proper space on the invitation to do so.

As a matter of English, the usual forms are

Mr & Mrs Smith
Mr & Mrs John Smith
Mr John Smith & Mrs Jane Smith
John and Jane Smith
John and Jane

The plain "Smith" and the "Mr/s" form seem a little dismissive as an acknowledgement, although "The Smiths" might work. Depending on the length of the surnames, you might also find that using a form without the titles may not be any shorter.

You should also consider your group's norms for what is socially acceptable.