Mouse gets stuck in lower edge of screen on portrait oriented window

Your monitors are probably logically (that is, in the computer's mind) set up like this:

+--------+ +---------+
|        | |         |
|        | |         |
|        | |         |
+--------+ |         |
           |         |
           |         |
           |         |
           |         |
           +---------+

Right-click on the desktop, and select "Screen Resolution". In the window that appears, you can drag the boxes around relative to each other. These boxes are your monitors. If you align them in there like they are on your desktop, it will be easier to move your mouse between the monitors.

For instance, my monitors are set up like this:

           +--------+
           |        |
+--------+ |        |
|        | |        |
|        | +--------+
|        |
+--------+

If the displays are not the same resolution, there is no way to do this. The borders are on a pixel to pixel ratio - the best you can do is to adjust the alignment in the screen resolution settings to be the way that you want it. There may be a third-party workaround, but I don't know of one off hand.

If the displays ARE the same resolution, this shouldn't be happening. Of course, that's unlikely to be the case here if you have a 22" in portrait because I assume the laptop is in landscape.

Amazing. I was having this issue only on the upper left corner of my middle monitor, going left. My original config was like this:

+--------+ +---------+ +-------+
|        | |         | |       |
|        | |         | |       |
|        | |         | |       |
+--------+ +---------+ +-------+

All I did was change it to this and it worked perfectl

+--------+
|        | +--------+ +--------+
|        | |        | |        |
|        | |        | |        |
+--------+ |        | |        |
           +--------+ +--------+

If the boxes don't show up correctly ... I just made the left screen the highest by a bit and the other two slightly lower.