Windows Server 2008 R2 - Remove Product Key to Force Reactivation after Deployment

Specify the KMS Client Setup Key in the sysprep answer file. Here's a list of keys for WS 2008 R2:

Windows Server 2008 R2 HPC Edition - FKJQ8-TMCVP-FRMR7-4WR42-3JCD7
Windows Server 2008 R2 Datacenter - 74YFP-3QFB3-KQT8W-PMXWJ-7M648
Windows Server 2008 R2 Enterprise - 489J6-VHDMP-X63PK-3K798-CPX3Y
Windows Server 2008 R2 for Itanium-Based Systems - GT63C-RJFQ3-4GMB6-BRFB9-CB83V
Windows Server 2008 R2 Standard - YC6KT-GKW9T-YTKYR-T4X34-R7VHC
Windows Web Server 2008 R2 - 6TPJF-RBVHG-WBW2R-86QPH-6RTM4

This will give them a 30 or 60 day grace period (provided you rearm the machine during sysprep) before forcing them to enter their own key (unless they run their own KMS server, in which case, it will just activate for them).