Do not wakeup Mac on mouse movements
Solution 1:
Go to System Preferences » Bluetooth » Advanced and turn off "Allow Bluetooth devices to wake this computer."
To wake the computer, you'll have to press the power button.
I do this because my iMac wakes itself up in the middle of the night.
Solution 2:
Kind of a dumb answer but whenever you step away from the desk you can flip the mouse upside down.