Integrate $\int \frac{\sin x \cos x}{\sin^4x + \cos^4x} \,dx$

$$ \frac{\sin x\cos x}{\sin^4 x + \cos^4 x} = \frac{\sin 2x}{2(1 - 2\sin^2x \cos^2 x)} = \frac{\sin 2x}{2 - (1-\cos 2x)(1 + \cos 2x)} $$

Substitute $u = \cos 2x$ to get $$ -\frac{1}{2}\int\frac{du}{1+u^2} = -\frac{1}{2}\arctan u = \color{blue}{-\frac{1}{2}\arctan (\cos 2x)} $$

First, some preliminary manipulation. $$\frac{\sin x \cos x}{\sin^4x + \cos^4x} = \frac{\sin x \cos x}{(1-\cos^2x)^2 + \cos^4x}\\=\frac{\sin x \cos x}{2\cos^4x -2\cos^2x+1}=\frac{4\sin x \cos x}{8\cos^4x -8\cos^2x+1 + 3}\\=\frac{4\sin x \cos x}{\cos4x+ 3}$$

The last step uses the quadruple angle formula for cosine. Now $\sin 2x = 2\sin x \cos x$, using this twice yields:$$\frac{4\sin x \cos x}{\cos4x+ 3}=\frac{2\sin 2x }{\cos4x+ 3} =\frac{2\sin 2x \cos 2x}{(\cos4x+ 3)\cos 2x} = \frac{\sin 4x }{(\cos4x+ 3)\cos 2x} $$

We can now use the half-angle formula for cosine, which is $\cos\frac{x}{2}=\sqrt{\frac{1+\cos x}{2}}$. $$\frac{\sin 4x }{(\cos4x+ 3)\cos 2x}=\frac{\sin 4x }{(\cos4x+ 3)\sqrt{\frac{1+\cos 4x}{2}}} \\=\frac{\sqrt{2} \times \sin 4x }{(\cos4x+ 3)\sqrt{\cos 4x + 3 - 2}}$$

The time is ripe to substitute with $u=\cos 4x +3$. Then $du = -4\sin 4x \ dx$ and $$\int \frac{\sqrt{2} \times \sin 4x }{(\cos4x+ 3)\sqrt{\cos 4x + 3 - 2}} \ dx\\ = \frac{\sqrt{2}}{-4}\int \frac{1}{u\sqrt{u - 2}} \ du$$

To finish this relatively simple integral, I did another substitution, this time with $t=\sqrt{u-2}$ and $du =2t \ dt$. $$\frac{\sqrt{2}}{-4}\int \frac{1}{u\sqrt{u - 2}} \ du = \frac{\sqrt{2}}{-4}\int \frac{2t}{ut} \ dt\\=\frac{\sqrt{2}}{-2}\int \frac{1}{t^2 +2} \ dt$$

This is an integral that involves $\arctan$:$$\frac{\sqrt{2}}{-2}\int \frac{1}{t^2 +2} \ dt=-\frac{1}{2}\arctan(\frac{t}{\sqrt{2}})=-\frac{1}{2}\arctan(\frac{\sqrt{u-2}}{\sqrt{2}})\\=-\frac{1}{2}\arctan(\sqrt{\frac{\cos 4x +1}{2}})=-\frac{1}{2} \arctan(\cos 2x)$$

Checking with wolframalpha, this differentiates to the correct result.

Hint:

Divide numerator & denominator by $\cos^4x$

and set $\tan^2x=u$

Alternatively, the divisor $=\sin^4x$

and the substitution $=\cot^2x=v$

$u = \cos 2t \implies du = -2\sin 2t dt$

$$\begin{align}\dfrac{-1}2\int \frac{\sin x \cos x}{\sin^4x + \cos^4x}\dfrac{du}{\sin 2t} =& \dfrac{-1}4\int \frac{1}{\sin^4x + \cos^4x}du &\\=& \dfrac{-1}2\int \frac{1}{(\cos^2x + \sin^2x)^2 +(\cos^2x - \sin^2x)^2 } &\\=& \dfrac{-1}2\int \frac{1}{1+u^2 }du = \dfrac{-1}{2}\tan^{-1}(\cos 2x) + C\end{align}$$