Are there disadvantages to switching companions? [duplicate]
Solution 1:
No, ditch 'em.
Once you get the perk it is permanent, and you won't lose approval for not traveling with them.
Obviously some companions are better than others. So, if you drop Cait, you won't be able to have her pick all the locks anymore, for example. And if you drop your romantic companion, then you won't be able to get Lover's Embrace so easily, but I don't think that's really what you're asking about. To clarify though, you can just switch back later and you won't have lost anything versus when you kicked them to the curb.