A word meaning an "indifferent resignation"?

Solution 1:

Acclimate - 1 Become accustomed to a new climate or to new conditions

1.1 Biology respond physiologically or behaviorally to a change in a single environmental factor

"Although I have severe myopia, I've lived with it all my live and have thereore acclimated myself to the condition."

While this is the best word I was able to come up with, in my opinion, this word is less about resignation than it is about adaptation. As such, it may not be a perfect match for your question.

You may want to consider instead: resigned.

Resigned - having accepted something unpleasant that one cannot do anything about.

You might also say you have "come to terms with it" or you have "accepted" your condition or "gotten used to it."