Where Is Machine.Config?

32-bit

%windir%\Microsoft.NET\Framework\[version]\config\machine.config

64-bit

%windir%\Microsoft.NET\Framework64\[version]\config\machine.config 

[version] should be equal to v1.0.3705, v1.1.4322, v2.0.50727 or v4.0.30319.

v3.0 and v3.5 just contain additional assemblies to v2.0.50727 so there should be no config\machine.config. v4.5.x and v4.6.x are stored inside v4.0.30319.

You can run this in powershell:

[System.Runtime.InteropServices.RuntimeEnvironment]::SystemConfigurationFile

Which outputs this for .net 4:

C:\Windows\Microsoft.NET\Framework\v4.0.30319\config\machine.config

Note however that this might change depending on whether .net is running as 32 or 64 bit which will result in \Framework\ or \Framework64\ respectively.

In order to be absolutely sure, slap a Label on an ASP.NET page and run this code:

labelDebug.Text = System.Runtime.InteropServices.RuntimeEnvironment.SystemConfigurationFile;

I believe this will leave no doubt!

It semi-depends though... mine is:

C:\Windows\Microsoft.NET\Framework\v2.0.50727\CONFIG

and

C:\Windows\Microsoft.NET\Framework64\v2.0.50727\CONFIG