How can I force Chrome to open links with specific profile?

With the current version of Chrome (51.0.2704.106 (64-bit)) you can just right-click an url and then open it with the fourth menu choice from top: "Open Link as PROFILE" (your configured Chrome profile).

EDIT: with the current Chrome version: 95.0.4638.69 (Official Build) (x86_64) (I tried the Intel CPU build, but should work for M1 version as well) it's possibile open the link in a different PROFILE when the target profile it's already open.

Here two images by example. Menu when the target PROFILE it's already open:

Menu without the target PROFILE already open:

I hope this helps.