iTunes opens automatically when CD inserted

I don't use iTunes, but I can't prevent it from automatically opening every time a CD is inserted.

I have already changed the system preferences for when a CD/DVD is inserted to "ignore" or to "open other program"-- but it seems that iTunes 12 overrides these system preferences.

I've also looked at the preferences within iTunes, but there is no option to "ignore" when CD is inserted (though I am almost certain there used to be!)

Try changing the system preference (as per your screenshot) for "when you insert a music CD" (or whichever one is causing you an issue) to "Open in iTunes" and then immediately back to "Ignore". For me that seemed to reset the preference to ignore.

Look at ~/Library/Preferences/com.apple.digihub.plist.

You might also try backing up the file, deleting it, and letting it get re-created.

See also: https://www.jamf.com/jamf-nation/third-party-products/files/408/apple-digihub-settings