How to toggle class using pure javascript in html

Solution 1:

Hover event is called "mouseenter" instead of "click".

<script type="text/javascript">
    function a(){
        this.classList.toggle('first');
        this.classList.toggle('sec');
    }
    document.querySelector('#container').addEventListener('mouseenter', a )
    document.querySelector('#container').addEventListener('mouseleave', a )
</script>

Solution 2:

While Tom Chung's approach definitely works, it's better to give mouseenter and mouseleave their own handler :

var container = document.querySelector('#container');

container.addEventListener('mouseenter', function(){
        this.classList.remove('first');
        this.classList.add('second');
})
container.addEventListener('mouseleave', function(){
        this.classList.add('first');
        this.classList.remove('second');
})
.first {
    background: green;
}

.second {
    background: orange;
}
<div id="container" class="first">
    TEST
</div>

(see also this Fiddle)