Can I change what happens to Astrid in the Dark Brotherhood quest line?

Note, the following are spoilers for TES: V, regarding Astrid:

No. You can't save her; no matter what you do, Astrid dies during the Death Incarnate quest.

If you really wanted, and you're playing on the PC, you may be able to use console commands to place her (RefID 0001BDE8) somewhere via moveto or placeatme. She will presumably operate based on her generic AI package or at the very least just stand there (as 0001BDE8 is the "regular" Astrid and the one you see in the above quest is a different technical entity, 0004D6D1).

I am very late, and am probably necro'ing this post. But there is a mod on the Nexus that allows you to bring her back and have her as a follower, voice of Cindy Robinson and all.

It is called Astrid Reborn.