How to create an encrypted volume on an external drive or flash drive
Solution 1:
The best way to do this is via Disk Utility in the Application/Utilities folder. Review pictures for better understanding
Select the disk you want to encrypt
Choose the format method as in the picture, making sure you choose the option with Encryption
Next time you connect the disk, you will be asked to enter password.
Solution 2:
You can create an encrypted volume using Disk Utility:
http://support.apple.com/kb/ht1578
Also, see here for information on FileVault:
Is File Vault 2 whole disk encryption or whole partition encryption?