Startup disk has no more space available for application memory?

Solution 1:

I've seen that message in programs like Photoshop that have their own virtual memory systems rather than just assuming the OS can handle RAM and memory allocation.

A reboot should clear things up. (safe mode boot might be nice if you want to run a full disk repair pass and then reboot normally)

Solution 2:

I've had the exact same problem. Running "Repair permissions" in Disk Utility cured it.

My problem was probably caused by using CleanMyMac which messes around with booth system and app folders.

Solution 3:

If you have a relatively new HP printer, the software that came with it can cause a massive memory leak. I have a 2 year old 27" core i7 iMac that suddenly started giving me the same error message. I tracked it down to the HP software. Once I completely removed the HP software the error never came back. HP has yet to fix this issue. http://h30434.www3.hp.com/t5/Mac-Printing-and-Scanning/HP-Device-Monitor-takes-130-of-CPU-and-800MB-of-RAM-while-idle/td-p/655701