href="tel:" and mobile numbers

When dialing a number within the country you are in, you still need to dial the national trunk number before the rest of the number. For example, in Australia one would dial:

   0 - trunk prefix
   2 - Area code for New South Wales
6555 - STD code for a specific telephone exchange
1234 - Telephone Exchange specific extension.

For a mobile phone this becomes

   0 -      trunk prefix
   4 -      Area code for a mobile telephone
1234 5678 - Mobile telephone number

Now, when I want to dial via the international trunk, you need to drop the trunk prefix and replace it with the international dialing prefix

   + -      Short hand for the country trunk number
  61 -      Country code for Australia
   4 -      Area code for a mobile telephone
1234 5678 - Mobile telephone number

This is why you often find that the first digit of a telephone number is dropped when dialling internationally, even when using international prefixing to dial within the same country.

So as per the trunk prefix for Germany drop the 0 and add the +49 for Germany's international calling code (for example) giving:

<a href="tel:+496170961709" class="Blondie">
    Call me, call me any, anytime
      <b>Call me (call me) I'll arrive</b>
        When you're ready we can share the wine!
</a>

I know the OP is asking about international country codes but for North America, you could use the following:

<a href="tel:+1-847-555-5555">1-847-555-5555</a>

<a href="tel:+18475555555">Click Here To Call Support 1-847-555-5555</a>

This might help you.

The BlackBerry browser and Safari for iOS (iPhone/iPod/iPad) automatically detect phone numbers and email addresses and convert them to links. If you don’t want this feature, you should use the following meta tags.

For Safari:

<meta name="format-detection" content="telephone=no">

For BlackBerry:

<meta http-equiv="x-rim-auto-match" content="none">

Source: mobilexweb.com

As an additional note, you may also add markup language for pausing or waiting, I learned this from the iPhone iOS which allows numbers to be stored with extension numbers in the same line. A semi-colon establishes a wait, which will show as a next step upon calling the number. This helps to simplify the workflow of calling numbers with extensions in their board. You press the button shown on the bottom left of the iPhone screen when prompted, and the iPhone will dial it automatically.

<a href="tel:+50225079227;1">Call Now</a>

The pause is entered with a comma ",", allowing a short pause of time for each comma. Once the time has passed, the number after the comma will be dialed automatically

<a href="tel:+50225079227,1">Call Now, you will be automaticlaly transferred</a>