Is it possible to change the aspect ratio of the zoom box in vlc media player?

My lectures are recorded in zoom and two screens are stacked together (the camera which records the lecturer and the screen with the presentation). There is an option to zoom in (Tools -> Effects and Filters -> Video Effects -> Interactive Zoom). However, the "zoom box" has the same aspect ratio as the original video. Here is a screenshot of the typical recording. But if I want to zoom in on one of the screens, it would be more appropriate to change the aspect ratio, so that it fits onto the screen of my laptop. Is it possible to do that?

No. The video was streamed out using 2 cameras but you received it as one sigle all-in package. VLC player (or any other player I'm aware of) contains no partial zoom facility.

What you want to do requires an actual video editor. There are many capable Open Source applications, such as OpenShot. Comparing the features of different applications you should be able to find one that suits your purpose.