Simulating mouse clicks at specific screen coordinates
Solution 1:
http://www.autohotkey.com/ (and its clones) provide such feature. you want to use especially the "Click"-Command:
Clicks a mouse button at the specified coordinates. It can also hold down a mouse button, turn the mouse wheel, or move the mouse.
Solution 2:
SendMode Play
SetKeyDelay, 0, 0, Play
F1::Click 42, 131
F2::ControlSend ahk_class main, Click, Championship Manager 01/02
return