How to disable the mouse wheel scrolling in mpv?

Solution 1:

If you click the search bar on the bottom left (next to the Windows start button) you'll then want to type in %appdata% and click enter on your keyboard.

This will bring you into your AppData/Roaming folder. Once you've reached this folder, you'll need to scroll down until you see the mpv folder. Double click that folder and inside you'll find input.conf. Open it up with an editor of your choice. I prefer visual studio code. Inside the input.conf editor add the following lines:

WHEEL_UP ignore
WHEEL_DOWN ignore

for a four-directional mouse:

WHEEL_RIGHT ignore 
WHEEL_LEFT ignore

Be sure to save your file afterwards.

source