Running 16-bit app on 64-bit is now possible? NTVDMx64
Solution 1:
NTVDMx64 is referred by several sources as trustworthy, but this is finally your decision to make. You should know that it's very slow and uses non-standard methods of loading programs.
You may also look at the following alternatives:
vDos (donationware) is better for most purposes
DOSBox is also a worthy alternative.