Can I use a PC hard disk drive for my PS3?

Solution 1:

IF you mean an external drive or somehow hooking your PS3 to your PC no, you can't install games on an external drive like that. You can however use a laptop 2.5" HDD and replace the physical HDD inside the PS3 (you can backup and restore your current saves to keep all your stuff too).

See this question for a bit more info on the HDD type you need Internal PS3 HDD Replacement

Solution 2:

The typical PC hard disk drive is not the correct size to be placed inside a PS3 console.

Solution 3:

No a normal PC hard disk drive the Sony support site states

The HDD must be a 2.5” internal Serial ATA HDD. Parallel ATA is not supported.

External Hard Drives though USB are supported.