How to Disable control of Youtube with Keyboard Media Keys

Solution 1:

  1. Load chrome://flags/#hardware-media-key-handling in the Chrome address bar; this should open the right flag when loaded.
  2. Set the Hardware Media Key Handling flag to Disabled.
  3. Restart Google Chrome.

Source: ghacks.net

Solution 2:

Found a solution need to go diable options in chrome flags : https://www.ghacks.net/2019/04/17/fix-chrome-blocking-keyboard-multimedia-keys-from-working/