What benefits does the 64-bit version of Notepad++ have over the 32-bit version?

Solution 1:

The Show Stopper for 64-bit is: "check if all plugins you need are available for 64 bit". ref. - https://community.notepad-plus-plus.org/topic/17356/change-from-32-bit-to-64-bit

As a longtime NotePad++ user, I have always chosen 32-bit to ensure a maximum selection of Plugins. I will, of course, review the list of plugins that don't work in 64-bit the next time I install NotePad++.

Solution 2:

It's the same reason as any other 64 bit vs 32 bit program; it's able to use more RAM. Therefore a 64-bit version of Notepad++ is most likely able to open and handle bigger files, than the 32-bit version.

Same question on Notepad++ forum