Ubuntu 21.10 desktop iso does not boot after installed to a usb removable drive

I just downloaded the Ubuntu 21.10 desktop iso and use the Ubuntu startup disk creator to explode the iso into a 64gb usb removable drive. Then i tried to boot from a laptop with this usb but it does not recognize it as a bootable drive.

After this disappointed event, i used a windows 10 with a portable version of Rufus (i follow these steps) to repeat the installation in the usb removable drive of the iso. Again it failed the boot in the laptop.

I tried it with a virtualbox machine and again, it does not boot.

I tried to erased the partions in the usb drive and tried all over again. Same results.

Am i doing something wrong or the available iso just does not have a bootable partion?

Thank you in advance for any miracle guidance you might have for me.

More details

• The bios of the laptop does not recognize the usb removable drive as having a bootable partion.
• The laptop is an old Samsung Series 9.
• The problem did not happen in the past. I did the same: downloaded a iso from ubuntu, used the utility to install it in the usb device, and boot from it in the laptop.
• i loaded the default values of the bios, just in case
• the same problem happens using a Virtualbox 6.1

I do not know what else information i can provide. This is a simple problem. Well, i will try with the 20.04 LTS iso.

Solution 1:

After all the problem was the Fast Boot of the bios: SecureBoot (Disabled) AND OS Mode Selection (CSM OS).

Thank you all for helping me solving this mystery.