Is it possible to disable USB port with known physical location?

Yes, this can be done with just a couple of commands in the terminal:

1. Disable the USB port:

   echo disabled | sudo tee /sys/bus/usb/devices/usb2/power/wakeup
   

2. Remove power from the port:

   echo suspend | sudo tee /sys/bus/usb/devices/usb2/power/level
   

In the event this doesn’t work, a udev rule may be necessary:

1. Create a new file in /lib/udev/rules.d using a text editor of your choice. For example:

   sudo vi /lib/udev/rules.d/20-block-webcam.rules
   

2. Revoke authorization for the webcam to be accessed:

   # Chicony Webcam
   SUBSYSTEM=="usb", ATTRS{idVendor}=="04f2", ATTRS{idProduct}=="b330", ATTR{authorized}="0"
   

   _{Looks like the output of lsusb did matter 😉}
3. Reboot

From comments:

Also it then maybe fixed by echo 0 | sudo tee /sys/bus/usb/devices/2-1.5/authorized as per https://www.kernel.org/doc/Documentation/usb/authorization.txt .
Put echo 0 > /sys/bus/usb/devices/2-1.5/authorized to /etc/rc.local.