Solution 1:

You could put a Border around the StackPanel and set a padding on that. I end up doing this a lot, since there are many UIElements that do not have a padding property.

<Border Padding="10">
    <StackPanel>
        <!--...-->
    </StackPanel>
</Border>

(Note: all FrameworkElements have a Margin property, which will space the element, but not include the margin width as part of the ActualWidth).

If you want to space the items inside a StackPanel, you'll want to add a margin to each child as Rob said.

Solution 2:

Or you could do something similar to TiM:

<Border>
    <StackPanel Margin="10">
        ...
    </StackPanel>
</Border>

Solution 3:

if you mean you want to space out child elements of the StackPanel (which doesn't have a Padding property), see: How do I space out the child elements of a StackPanel?