Does the location of Great Works matter?

Solution 1:

The number of Great Works in a given city does not, in and of itself, make a difference, nor do the location of the city, nor the nature of the work, but once you start getting buildings with more than one slot, there is the opportunity for Theming Bonuses if you have multiple Great Works in the same building, meeting certain conditions.

As well, there are a number of different effects from various buildings, wonders, or civilizations' unique abilities, which can provide bonuses to tourism generated in a given city, so stacking multiple Great Works in a city with such bonuses will mean more Great Works getting the bonus.

Lastly, any time a city is captured, any Great Works still in that city are also captured, which makes border cities a little riskier. However, because you can move Great Works instantly across any distance as long as it's your turn, you can usually move them out when a city is under siege and losing, before it's taken, as long as you remember.