Horrible redraw performance of the DataGridView on one of my two screens

You just need to make a custom class based off of DataGridView so you can enable its DoubleBuffering. That's it!

class CustomDataGridView: DataGridView
{
    public CustomDataGridView()
    {
        DoubleBuffered = true;
    } 
}

As long as all of my instances of the grid are using this custom version, all is well. If I ever run into a situation caused by this where I'm not able to use the subclass solution (if I don't have the code), I suppose I could try to inject that control onto the form :) (although I'll be more likely to try using reflection to force the DoubleBuffered property on from the outside to once again avoid the dependency).

It is sad that such a trivially simple thing ate up so much of my time...

Note: Making the answer an answer so the question can be marked as answered

Here is some code that sets the property using reflection, without subclassing as Benoit suggests.

typeof(DataGridView).InvokeMember(
   "DoubleBuffered", 
   BindingFlags.NonPublic | BindingFlags.Instance | BindingFlags.SetProperty,
   null, 
   myDataGridViewObject, 
   new object[] { true });