How to change the display theme in Adobe Acrobat Reader permanently?

Anyone still interested see: https://www.quora.com/How-do-I-use-night-mode-in-Adobe-reader-in-pc.

• Open Adobe Reader, go to Edit menu & select Preferences from the drop-down. Preferences window will pop up on the screen.
• Choose Accessibility from the Categories section.
• Now check the Replace Document Color box.
• In front of Custom Color Please change the Page Background to Black & Text Document to White.
• Click OK to confirm the changes.

This will give you the similar result as that of Night mode in Mobile Adobe.

Try using the following registry key:

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\DC\AVGeneral] "aActiveUITheme"="DarkTheme"

If you copy/paste in a .reg file and run it will work straight.

I don't know if this will be persistent but worths at least you try.