FtpWebRequest "The remote certificate is invalid according to the validation procedure"

You have to overwrite the certificate checks so that they will always be considered good. That won't prevent the channel to remain SSL protected.

Uri target = new Uri("ftp://yourUri");
string fileName = @"fullPathOfYourFile";
FtpWebRequest request = (FtpWebRequest)WebRequest.Create(target);
request.Method = WebRequestMethods.Ftp.UploadFile;
request.Credentials = new NetworkCredential("user", "password");
request.EnableSsl = true;

//overwrite the certificate checks
ServicePointManager.ServerCertificateValidationCallback = 
                      (s, certificate, chain, sslPolicyErrors) => true;

// Copy the contents of the file to the request stream
//....

The most voted answer by @Luca blindly accepts any certificate. That's a security flaw.

When implementing ServicePointManager.ServerCertificateValidation callback one should validate the certificate. E.g. by checking certificate's hash against a known value:

using System.Net;
using System.Net.Security;
using System.Security.Cryptography;

ServicePointManager.ServerCertificateValidationCallback +=
    (sender, certificate, chain, errors) =>
    {
        return
            (errors == SslPolicyErrors.None) ||
            certificate.GetCertHashString(HashAlgorithmName.SHA256).Equals(
                "EB8E0B28AE064ED58CBED9DAEB46CFEB3BD7ECA677...");
    };

For the X509Certificate.GetCertHashString overload that takes HashAlgorithmName.SHA256, you need .NET 4.8. On older versions use the parameter-less overload that returns an SHA-1 hash.

Based on Is it safe to test the X509Certificate.Thumbprint property when you know an invalid certificate is safe?

For VB.NET version of the code, see Accept self-signed TLS/SSL certificate in VB.NET.