Is the Serre spectral sequence a special case of the Leray spectral sequence?
Solution 1:
Yes. In fact, the result is basically obvious if you use Czech cohomology on the base.
Serre really had two key insights. First, sheaf cohomology is a pain to compute, but if there is no fundamental group then for fiber bundles the Leray spectral sequence is really just using normal old-fashioned untwisted cohomology. Second, you don't really need to work with fiber bundles -- all you need are Serre fibrations, and those are easy to construct. In particular, you have the standard Serre fibration $\Omega X \rightarrow PX \rightarrow X$, where $\Omega X$ is the loop space of $X$ and $PX$ is the space of paths starting at the basepoint of $X$ and the map $PX \rightarrow X$ is "evaluation at the endpoint". Clearly $PX$ is contractible! An amazing amount of milage can be had from this silly observation!
Serre also really developed many of the key algebraic tricks one needs to work with spectral sequences. For instance, he had the amazing idea that one can work modulo "Serre classes", and thus ignore things like torsion. It's like pretending to localize spaces long before Sullivan and Quillen realized you could do so for real!