Microsoft Office 2010 Word not saving

I create a new file on Word 2010. I type a few words. Then I press Ctrl + S to save it or click on the diskette icon on the toolbar. But Word does not save. Does nothing. When I want to close the file clicking the X button of the window, it prompts me if I want to save the changes or not.

Then I have uninstall MS Office 2010 and installed MS Office 2013. I wanted to understand if the problem is sourced by wrong configuration and/or settings. But NO!

The same problem persists on MS Office 2013 Std too.

I have searched for similar problems on Google, but found no helpful solution. I think it is a macro virus but do not know how to overcome it.

UPDATE by Art Gertner:

Experiencing identical problem. Excel and PowerPoint also affected. Attempted the following:

• Restarting PC
• Deleting Normal.dot
• Starting in safe mode (winword /safe)
• Disabling all addons
• Cleaning up c:/temp
• Checking Office activation status (shows valid license)
• Checking that default file location in word (options > save > default file location) is valid path
• Creating a new user account (issue is still present)
• Checking the file system with chkdsk /r (no effect)

Additional details:

• OS: Windows 7 x64 pro. Office 2010
• Disk encryption is not used
• the issue used to be intermittent for several days. Used to disappear after restart. Now it is permanent. Cannot save documents at all.
• File > Open and File > save actions are also affected (nothing happens when clicked)
• The following workaround is valid. Use windows explorer to navigate to directory where you want to save the file. Right click to call context menu. Select New > Microsoft Word Document. Document is created. Any changes to this document will be successfully saved.

The Only answer I could find for this problem was to create a new user account and move data over.

My customer said:

It was random initially and then became frequent and then permanent and then spread from MS Office products to other programs as well.

Creating a new user account might not be the most ideal thing for everyone but I had to give up & move on at some point. :( looser

Different stuffs I tried in two days are below:

1. Not only disable the add-ins but uninstall programs which had any add-in for Office Apps like Mcafee & Lexmark printer toolbar
2. Clean boot the computer
3. Plug HDD to a different computer and run virus/malware scans
4. Tried Office apps in safe mode for sure
5. Disconnect Network drives as I have seen them causing problem with file Save & Open action at times in past

6. Played around with Process Monitor, compared then deleted and re-created following registry keys with another similar system.

   HKCU\Software\Microsoft\Office\16.0\Common\OpenFind\MicrosoftWord\Settings\SaveAs

   HKCU\Software\Microsoft\Windows\CurrentVersion\Explorer\CIDSave

   HKCU\Software\Microsoft\Windows\CurrentVersion\Explorer\ComDlg32

7. Ran chkdsk /r

8. Re-installed MS Office too
9. No component store corruption detected on DISM /CheckHealth & /ScanHealth
10. Didn't try System File Checker because I haven't been lucky with it ever

Affected system was a Windows 10 with Office 2013 installed, Which I upgraded to Office 16 later and the problem was still there until a new User account was created

Try running a c:\>sfc /scannow

The comdlg32.dll may be corrupted. This DLL gets referenced when you want to open or save a document in Office.