Are web-safe colors still relevant?

Since the vast majority of monitors are 16-bit color or more, including mobile devices, does it make sense to even consider web-safe colors when choosing color schemes? Or is it something that ought to be relegated to history as a piece of trivia?

For those of you that don't know what web-safe colors are:

Another set of 216 color values is commonly considered to be the "web-safe" color palette, developed at a time when many computer displays were only capable of displaying 256 colors. A set of colors was needed that could be shown without dithering on 256-color displays; the number 216 was chosen partly because computer operating systems customarily reserved sixteen to twenty colors for their own use; it was also selected because it allows exactly six shades each of red, green, and blue (6 × 6 × 6 = 216).

The list of colors is often presented as if it has special properties that render them immune to dithering. In fact, on 256-color displays applications can set a palette of any selection of colors that they choose, dithering the rest. These colors were chosen specifically because they matched the palettes selected by the then leading browser applications. ^[Wikipedia]

For me web safe color palette is no longer primary concern. Optimize for the largest target audience.

According to w3schools site visitors:

• In January 2009 1% of site visitors had 256 color displays, 95% of users had 24 or 32 bit.
• [Update] In January 2015 0.5% had 256 colours, 0.5% had 24 bit and 99% had 32 bit

I found similar numbers from a business app site that I look after:

32-bit  79.01%  

24-bit  15.64%  

16-bit  5.27%   

8-bit   0.08%

I don't think web safe colors are relevant any more. To me, a much bigger problem for smartphones are all the fixed-width 960-pixel wide web pages.

I think the most important thing when choosing a colour palette is keeping in mind colour-blindness. There are a few different types that I know of, but the main thing is making sure that you have enough contrast between colours.

For example green text on a red background might be easier for some to read, but very difficult or maybe impossible for others (5-10% of males!), especially if the values of the colours are close.

For those of us (like me) that didn't know exactly what web safe colors are, they were

developed at a time when many computer displays were only capable of displaying 256 colors. A set of colors was needed that could be shown without dithering on 256-color displays; the number 216 was chosen partly because computer operating systems customarily reserved sixteen to twenty colors for their own use; it was also selected because it allows exactly six shades each of red, green, and blue (6 × 6 × 6 = 216).

The list of colors is often presented as if it has special properties that render them immune to dithering. In fact, on 256-color displays applications can set a palette of any selection of colors that they choose, dithering the rest. These colors were chosen specifically because they matched the palettes selected by the then leading browser applications.

It's hard to imagine any of this applying to today's modern displays, since almost nobody runs their display in 256 colors anymore (unless perhaps they are playing an old version of Leisure Suit Larry).

In my opinion, its history.