Is it possible to have different zoom for each display for dual-display configuration?
This should do the trick. Replace $YOUR_4K_SCREEN
with the name of your output. You can play with the scaling factor until it's comfortable for you.
xrandr --output $YOUR_4K_SCREEN --scale 0.5x0.5
If anyone knows how to make this persist let us know.
If you encounter overlapping issue on second monitor use arandr to set screen position
sudo apt install arandr